Context-sensitive half-time of fentanyl in dogs

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Context-sensitive half-time of fentanyl in dogs

Context-sensitive half-times (CSHTs) of fentanyl in dogs were determined using pharmacokinetic models reported by Murphy et al. and Sano et al., and compared with a human model. The CSHT was defined as the time required for a 50% decrease in drug concentration in the central compartment after the termination of infusion. Although CSHTs increased gradually as the infusion time increased, the CSH...

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Note Pharmacology 1 2 Context - sensitive half - time of fentanyl in dogs 3 4

20 Context-sensitive half-times (CSHTs) of fentanyl in dogs were determined using 21 pharmacokinetic models reported by Murphy et al. and Sano et al., and compared with a 22 human model. The CSHT was defined as the time required for a 50% decrease in drug 23 concentration in the central compartment after the termination of infusion. Although 24 CSHTs increased gradually as the infusion time inc...

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ژورنال

عنوان ژورنال: Journal of Veterinary Medical Science

سال: 2015

ISSN: 0916-7250,1347-7439

DOI: 10.1292/jvms.14-0549